Physiological predictors of resting pulmonary hypertension associated with COPD: a retrospective analysis

Abstract Background Resting pulmonary hypertension (PH) is not uncommon in patients with chronic obstructive disease (COPD). In the current study, we aimed to identify physiological predictors of resting PH COPD. Methods We retrospectively analyzed data derived from right heart catheterization sixty-nine stable Patients were categorized into COPD-PH ( n = 33) and COPD-non-PH 36), based on “6 th World Symposium PH.” Results Demographics, forced expiratory volume 1 s (FEV ), lung volumes, cardiac output, index similar between groups, yet had greater vascular resistance (PVR) lower PaO 2 P < 0.05). The proportion did differ across range FEV χ 3.01, 0.22). No correlations found PVR degree airflow obstruction or hyperinflation. was only predictor both artery pressure PVR. Conclusions Increased PVR, response arterial hypoxemia directly induced by tobacco smoking, likely key factor that led sample moderate-severe COPD, regardless limitation